Chronic itching can be a side effect of opioid use. The best way to stop an opioid itch is to stop using opioids. If you are struggling to quit opioids, medications like Suboxone can help.
Suboxone is a partial opioid itself and can, like other opioids, also sometimes cause itching. If you develop itching while using Suboxone, your doctor may adjust your dose or try a different medication to help you with OUD.
Researchers aren't sure why opioids make people itch.[1] They know that the drugs interact with receptors along the spinal cord and skin, and it's possible those connections trigger nerve pain we interpret as an itch.
Some researchers note that opioids cause blood vessels to dilate, and some people develop reddened skin.[2] Those changes indicate histamines are released, and these chemicals might be associated with itching.
Some people with opioid itch benefit from over-the-counter antihistamine medications. But many people find the itch stays with them no matter the medications they try.
Researchers are examining the medication nalfurafine hydrochloride, which targets cells inside the spinal cord.[3] Preliminary studies suggest that it's very helpful for people with chronic itch problems. But it's not yet widely available in the United States.
The best treatment for opioid related itching at this time is to discontinue opioids. However, this is much easier said than done, particularly if you have a dependence on opioid medications.
If you are trying to discontinue opioid use, MAT therapies like buprenorphine are less likely to cause itch than other opioids, and might be a good choice for you. Talk to your doctor about starting Suboxone for OUD.
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